中国传统行政文化的价值再现

文章对中国传统行政文化的利弊优劣，进行了正反两方面的理性分析，并依据市场经济发展的客观形势，预测人本主义、依法行政的现代走向。     

关于差分式放大器输入电阻的研究

差分式放大器在实际应用方面非常广泛,其理论分析方法的深入研究,对生产实践和教学都有重要的意义。采用电路理论分析、差放理论分析、“虚短”理论分析及实验的方法对差分式放大电路进行了研究。     

Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

激光光束质量的评价方法

激光光束质量是一个很有现实意义的论题，对不同应用的激光光束其质量的评价标准一般不同。给出了几种有代表性的激光光束质量的评价方法，并分别对各种评价标准的合理性与适用性进行了详细的分析；研究了实际应用中对激光光束质量的一些要求和相关的评价参数。     

高贵心灵的无声抗争——《女勇士》与《红字》两则故事相似性之比较

华裔美国女作家汤婷婷的作品《女勇士》中无名女人的故事与美国19世纪浪漫主义小说家纳塞尼尔·霍桑的代表作《红字》中海斯特·白兰的故事都是有关通奸的故事，虽写于不同的时代，但两个故事有着惊人的相似性。本文从两个故事的发生原因，结果以及两位女主人公对通奸行为的态度三个方面简要分析两种通奸行为，旨在阐明通奸行为是两个女人对自由和爱情的追求以及她们对当时父权社会的反抗。     

Specific anti-tumor effect induced by attenuated Salmonella typhimurium vaccine expressing extracellular region of vascular endothelial growth factor receptor 2

The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors.     

椭圆偏振法研究四方氧化锆对Zr-Sn-Nb合金氧化膜耐腐蚀性能的影响

将经过不同热处理的Zr-Sn-Nb合金样品放在350℃、16．8mol／LPa、0．01mol／LLiOH溶液的高压釜中进行腐蚀。用椭圆偏振法研究氧化膜中的四方氧化锆，发现经过580℃／冷轧／500℃处理的样品在腐蚀42天和190天后氧化膜中的四方氧化锆比其它样品的多。四方氧化锆是影响合金耐腐蚀性能的一个主要因素，四方氧化锆的形成有利于提高合金的耐腐蚀性能。     

Regulation of insulin receptor function

Resistance to the biological actions of insulin contributes to the development of type 2 diabetes and risk of cardiovascular disease. A reduced biological response to insulin by tissues results from an impairment in the cascade of phosphorylation events within cells that regulate the activity of enzymes comprising the insulin signaling pathway. In most models of insulin resistance, there is evidence that this decrement in insulin signaling begins with either the activation or substrate kinase activity of the insulin receptor (IR), which is the only component of the pathway that is unique to insulin action. Activation of the IR can be impaired by post-translational modifications of the protein involving serine phosphorylation, or by binding to inhibiting proteins such as PC-1 or members of the SOCS or Grb protein families. The impact of these processes on the conformational changes and phosphorylation events required for full signaling activity, as well as the role of these mechanisms in human disease, is reviewed in this article. Received 3 August 2006; received after revision 1 December 2006; accepted 8 January 2007     

我国存货准则与IAS2的比较与思考

我国已经颁布了新的存货准则,并于今年年初开始实施,这对于进一步规范企业存货的确认、计量和披露,提高会计信息的相关性和可靠性,完善我国会计准则体系,推动我国证券市场乃至整个社会主义市场经济的发展,将起到积极的作用.